ABOLISHED KETAMINE EFFECTS ON THE SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENT OF MEDIAL PREFRONTAL CORTEX NEURONS IN GLUN2D KNOCKOUT MICE

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice

Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor Console (NMDAR), generates a rapidly-acting antidepressant effect.It exerts psychomimetic effects, yet demands a further investigation of its mechanism.Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which

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Assignment of Focus Position with Convolutional Neural Networks in Adaptive Lens Based Axial Scanning for Confocal Microscopy

Adaptive lenses offer axial scanning without mechanical translation and thus are promising to replace mechanical-movement-based axial scanning in microscopy.The scan is accomplished by sweeping the applied voltage.However, the relation between the applied voltage and the resulting axial focus position is not unambiguous.Adaptive lenses suffer from

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The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion

Stroke ranks as One Drawer Nightstand the second most significant contributor to mortality worldwide and is a major factor in disability.Ischemic strokes account for 71% of all stroke incidences globally.The foremost approach to treating ischemic stroke prioritizes quick reperfusion, involving methods such as intravenous thrombolysis and endovascul

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